Drug interactions
Enalapril-hydrochlorothiazide + Epoprostenol
Severity: Moderate
Enalapril-hydrochlorothiazide and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, and combined with enalapril and hydrochlorothiazide it can add to blood pressure lowering. Hypotension may occur, especially after dose changes.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure closely when starting or titrating epoprostenol and reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Epoprostenol?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator, and combined with enalapril and hydrochlorothiazide it can add to blood pressure lowering. Hypotension may occur, especially after dose changes.
How serious is the interaction between Enalapril-hydrochlorothiazide and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when starting or titrating epoprostenol and reduce antihypertensive doses if hypotension develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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