Drug interactions
Enalapril-hydrochlorothiazide + Nateglinide
Severity: Minor
Enalapril-hydrochlorothiazide and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can increase blood glucose and reduce the effectiveness of insulin secretagogues like nateglinide. The effect is usually small at low thiazide doses but may be noticeable in poorly controlled diabetes.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia, partly through hypokalemia and reduced insulin secretion, opposes nateglinide.
What to do
Monitor blood glucose when starting or adjusting the thiazide and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Nateglinide?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can increase blood glucose and reduce the effectiveness of insulin secretagogues like nateglinide. The effect is usually small at low thiazide doses but may be noticeable in poorly controlled diabetes.
How serious is the interaction between Enalapril-hydrochlorothiazide and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting the thiazide and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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