Drug interactions
Enalapril-hydrochlorothiazide + Ofloxacin
Severity: Minor
Enalapril-hydrochlorothiazide and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is renally eliminated and diuretic-related volume depletion or reduced renal function could raise its levels. Fluoroquinolones also carry a risk of QT prolongation, which is worsened by thiazide-induced hypokalemia or hypomagnesemia. The overall effect is generally small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible reduced renal clearance of ofloxacin, plus electrolyte disturbances from the thiazide that increase QT-related risk.
What to do
Check potassium and magnesium in at-risk patients and adjust the ofloxacin dose for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Ofloxacin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is renally eliminated and diuretic-related volume depletion or reduced renal function could raise its levels. Fluoroquinolones also carry a risk of QT prolongation, which is worsened by thiazide-induced hypokalemia or hypomagnesemia. The overall effect is generally small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium in at-risk patients and adjust the ofloxacin dose for renal function.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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