Drug interactions
Enalapril-hydrochlorothiazide + Patiromer
Severity: Minor
Enalapril-hydrochlorothiazide and Patiromer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer binds some oral drugs in the gut in vitro, but no clinically important interaction with enalapril or hydrochlorothiazide has been observed. Patiromer is often used to enable continued ACE inhibitor therapy by controlling potassium.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Patiromer belongs to Miscellaneous.
Why it happens
Patiromer is a nonspecific cation-binding polymer that could theoretically bind drugs in the gut, but this was not clinically relevant here.
What to do
No dose separation is generally required for these drugs; monitor serum potassium and magnesium during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Patiromer?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Patiromer binds some oral drugs in the gut in vitro, but no clinically important interaction with enalapril or hydrochlorothiazide has been observed. Patiromer is often used to enable continued ACE inhibitor therapy by controlling potassium.
How serious is the interaction between Enalapril-hydrochlorothiazide and Patiromer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose separation is generally required for these drugs; monitor serum potassium and magnesium during therapy.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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