Drug interactions
Enalapril-hydrochlorothiazide + Prednisolone
Severity: Moderate
Enalapril-hydrochlorothiazide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone can increase urinary potassium loss, adding to that of hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged therapy. Corticosteroids may also raise blood pressure and blunt antihypertensive effect.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from corticosteroid and thiazide effects.
What to do
Monitor serum potassium and blood pressure during prolonged or high-dose therapy and replace potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Prednisolone?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisolone can increase urinary potassium loss, adding to that of hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged therapy. Corticosteroids may also raise blood pressure and blunt antihypertensive effect.
How serious is the interaction between Enalapril-hydrochlorothiazide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during prolonged or high-dose therapy and replace potassium if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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