Drug interactions
Enalapril-hydrochlorothiazide + Quinine
Severity: Minor
Enalapril-hydrochlorothiazide and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and quinine may compete for renal tubular secretion, which could modestly raise quinine exposure. Clinical consequences are not well documented. Thiazide-induced hypokalemia or hypomagnesemia could also add to quinine QT risk.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular cationic secretion, plus electrolyte disturbance from the thiazide that may add to QT effects.
What to do
No routine dose change is needed. Check potassium and magnesium when quinine is given to a patient on a thiazide and correct any deficits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Quinine?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and quinine may compete for renal tubular secretion, which could modestly raise quinine exposure. Clinical consequences are not well documented. Thiazide-induced hypokalemia or hypomagnesemia could also add to quinine QT risk.
How serious is the interaction between Enalapril-hydrochlorothiazide and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check potassium and magnesium when quinine is given to a patient on a thiazide and correct any deficits.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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