Drug interactions
Enalapril-hydrochlorothiazide + Timolol
Severity: Minor
Enalapril-hydrochlorothiazide and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol adds to the blood pressure lowering of the combination and can cause bradycardia or hypotension. Thiazide-related effects on potassium and glucose may also matter, and systemic absorption from eye drops is possible.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and heart rate after starting or changing doses. Check potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Timolol?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Timolol adds to the blood pressure lowering of the combination and can cause bradycardia or hypotension. Thiazide-related effects on potassium and glucose may also matter, and systemic absorption from eye drops is possible.
How serious is the interaction between Enalapril-hydrochlorothiazide and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or changing doses. Check potassium periodically.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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