Drug interactions
Enalapril-hydrochlorothiazide + Tretinoin
Severity: Minor
Enalapril-hydrochlorothiazide and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and tretinoin makes skin more sensitive to sunlight, so concurrent use may increase sunburn and phototoxic reactions. The effect applies mainly to exposed skin and is generally manageable with sun protection.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects; thiazides sensitize skin to UV light while retinoids thin the stratum corneum and increase UV susceptibility.
What to do
Advise strict sun avoidance, broad-spectrum sunscreen and protective clothing. Reduce tretinoin use or review the thiazide if significant photosensitivity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Tretinoin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is a recognized photosensitizer, and tretinoin makes skin more sensitive to sunlight, so concurrent use may increase sunburn and phototoxic reactions. The effect applies mainly to exposed skin and is generally manageable with sun protection.
How serious is the interaction between Enalapril-hydrochlorothiazide and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun avoidance, broad-spectrum sunscreen and protective clothing. Reduce tretinoin use or review the thiazide if significant photosensitivity occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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