Drug interactions
Enalapril-hydrochlorothiazide + Valganciclovir
Severity: Minor
Enalapril-hydrochlorothiazide and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with ganciclovir, the active metabolite of valganciclovir, for renal tubular secretion. Reduced renal function from diuretic-related volume depletion could also raise ganciclovir exposure and hematologic toxicity risk.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular anionic secretion and reduced renal clearance with volume depletion.
What to do
Monitor blood counts and renal function, and adjust valganciclovir dose to creatinine clearance as per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Valganciclovir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with ganciclovir, the active metabolite of valganciclovir, for renal tubular secretion. Reduced renal function from diuretic-related volume depletion could also raise ganciclovir exposure and hematologic toxicity risk.
How serious is the interaction between Enalapril-hydrochlorothiazide and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, and adjust valganciclovir dose to creatinine clearance as per labeling.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
