Drug interactions
Encainide + Haloperidol
Severity: Moderate
Encainide and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 and could increase concentrations of encainide, a CYP2D6 substrate, shifting the balance between parent drug and active metabolites. Proarrhythmic effects are a theoretical concern, and encainide is no longer widely marketed.
What this interaction means in plain words
Encainide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism of encainide by haloperidol.
What to do
Monitor ECG for QRS and QT changes if the combination is unavoidable. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Encainide with Haloperidol?
MediHelp rates the interaction as moderate. Encainide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol inhibits CYP2D6 and could increase concentrations of encainide, a CYP2D6 substrate, shifting the balance between parent drug and active metabolites. Proarrhythmic effects are a theoretical concern, and encainide is no longer widely marketed.
How serious is the interaction between Encainide and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QRS and QT changes if the combination is unavoidable. Consider an alternative antiarrhythmic.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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