Drug interactions
Encainide + Perphenazine
Severity: Moderate
Encainide and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine inhibits CYP2D6, which converts encainide to its active metabolites. Altered encainide and metabolite exposure could affect antiarrhythmic effect and proarrhythmic risk. Encainide is no longer widely marketed.
What this interaction means in plain words
Encainide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Perphenazine inhibits CYP2D6-mediated metabolism of encainide.
What to do
Monitor ECG and clinical response, and adjust the encainide dose if QRS widening or arrhythmias appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Encainide with Perphenazine?
MediHelp rates the interaction as moderate. Encainide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine inhibits CYP2D6, which converts encainide to its active metabolites. Altered encainide and metabolite exposure could affect antiarrhythmic effect and proarrhythmic risk. Encainide is no longer widely marketed.
How serious is the interaction between Encainide and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and clinical response, and adjust the encainide dose if QRS widening or arrhythmias appear.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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