Drug interactions
Encorafenib + Eplerenone
Severity: Moderate
Encorafenib and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has both inhibiting and inducing effects on CYP3A4, so eplerenone exposure may rise or fall unpredictably. Higher exposure raises hyperkalemia risk, whereas lower exposure reduces efficacy.
What this interaction means in plain words
Encorafenib and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Eplerenone belongs to Cardiovascular.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib alters eplerenone metabolism.
What to do
Monitor serum potassium, blood pressure and clinical response when starting or stopping encorafenib. Adjust eplerenone dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Eplerenone?
MediHelp rates the interaction as moderate. Encorafenib and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has both inhibiting and inducing effects on CYP3A4, so eplerenone exposure may rise or fall unpredictably. Higher exposure raises hyperkalemia risk, whereas lower exposure reduces efficacy.
How serious is the interaction between Encorafenib and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, blood pressure and clinical response when starting or stopping encorafenib. Adjust eplerenone dose accordingly.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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