Drug interactions
Encorafenib + Fluvoxamine
Severity: Moderate
Encorafenib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval, and fluvoxamine adds a small effect. Fluvoxamine may also raise encorafenib exposure through CYP3A4 inhibition.
What this interaction means in plain words
Encorafenib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition raising encorafenib levels.
What to do
Monitor ECG and electrolytes, and consider an alternative antidepressant. Reduce the encorafenib dose per labeling if a strong inhibitor is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Fluvoxamine?
MediHelp rates the interaction as moderate. Encorafenib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong the QT interval, and fluvoxamine adds a small effect. Fluvoxamine may also raise encorafenib exposure through CYP3A4 inhibition.
How serious is the interaction between Encorafenib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and consider an alternative antidepressant. Reduce the encorafenib dose per labeling if a strong inhibitor is needed.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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