Drug interactions
Encorafenib + Itraconazole
Severity: Major
Encorafenib and Itraconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises encorafenib exposure through CYP3A4 inhibition, increasing adverse effects. Both drugs can prolong QT, adding to arrhythmia risk.
What this interaction means in plain words
Encorafenib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases encorafenib clearance, plus additive QT prolongation.
What to do
Avoid if possible. If unavoidable, reduce encorafenib to the labeled lower dose, monitor ECG and electrolytes, and restore the dose after the inhibitor has been stopped for several half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Itraconazole?
MediHelp rates the interaction as major. Encorafenib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises encorafenib exposure through CYP3A4 inhibition, increasing adverse effects. Both drugs can prolong QT, adding to arrhythmia risk.
How serious is the interaction between Encorafenib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce encorafenib to the labeled lower dose, monitor ECG and electrolytes, and restore the dose after the inhibitor has been stopped for several half-lives.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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