Drug interactions
Encorafenib + Losartan
Severity: Moderate
Encorafenib and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has both inhibitory and inducing effects on CYP3A4, so losartan exposure and formation of its active metabolite may change unpredictably. This could result in reduced blood pressure control or increased effect.
What this interaction means in plain words
Encorafenib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib, affecting losartan metabolism.
What to do
Monitor blood pressure and adjust losartan dose to response when encorafenib is started, changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Losartan?
MediHelp rates the interaction as moderate. Encorafenib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has both inhibitory and inducing effects on CYP3A4, so losartan exposure and formation of its active metabolite may change unpredictably. This could result in reduced blood pressure control or increased effect.
How serious is the interaction between Encorafenib and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust losartan dose to response when encorafenib is started, changed or stopped.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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