Drug interactions
Encorafenib + Lovastatin
Severity: Moderate
Encorafenib and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib affects CYP3A4 in both directions and inhibits OATP1B1, OATP1B3 and BCRP. Lovastatin exposure may therefore change unpredictably, with a risk of myopathy if levels rise or loss of efficacy if they fall.
What this interaction means in plain words
Encorafenib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Lovastatin belongs to Cardiovascular.
Why it happens
Encorafenib inhibits and induces CYP3A4 and inhibits hepatic uptake and efflux transporters involved in statin disposition.
What to do
Monitor for muscle symptoms and CK, and review lipid response; consider a different statin less dependent on CYP3A4 if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Lovastatin?
MediHelp rates the interaction as moderate. Encorafenib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib affects CYP3A4 in both directions and inhibits OATP1B1, OATP1B3 and BCRP. Lovastatin exposure may therefore change unpredictably, with a risk of myopathy if levels rise or loss of efficacy if they fall.
How serious is the interaction between Encorafenib and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and CK, and review lipid response; consider a different statin less dependent on CYP3A4 if problems arise.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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