Drug interactions
Encorafenib + Lurasidone
Severity: Moderate
Encorafenib and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, and lurasidone is a sensitive CYP3A4 substrate. The net effect on lurasidone exposure is unpredictable, so levels may rise, with more adverse effects, or fall, with loss of efficacy.
What this interaction means in plain words
Encorafenib and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib, altering lurasidone metabolism.
What to do
Monitor for lurasidone adverse effects such as akathisia, sedation and parkinsonism, and for loss of psychiatric control. Adjust the lurasidone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Lurasidone?
MediHelp rates the interaction as moderate. Encorafenib and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, and lurasidone is a sensitive CYP3A4 substrate. The net effect on lurasidone exposure is unpredictable, so levels may rise, with more adverse effects, or fall, with loss of efficacy.
How serious is the interaction between Encorafenib and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lurasidone adverse effects such as akathisia, sedation and parkinsonism, and for loss of psychiatric control. Adjust the lurasidone dose according to clinical response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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