Drug interactions
Encorafenib + Mefloquine
Severity: Major
Encorafenib and Mefloquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-related QT prolongation, and mefloquine may add to this effect. Together they increase the risk of torsades de pointes, particularly with electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Encorafenib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination if possible and use a non-QT-prolonging antimalarial. If necessary, monitor ECG and electrolytes regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Mefloquine?
MediHelp rates the interaction as major. Encorafenib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib causes dose-related QT prolongation, and mefloquine may add to this effect. Together they increase the risk of torsades de pointes, particularly with electrolyte disturbance or underlying heart disease.
How serious is the interaction between Encorafenib and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-QT-prolonging antimalarial. If necessary, monitor ECG and electrolytes regularly.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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