Drug interactions
Encorafenib + Moxifloxacin
Severity: Major
Encorafenib and Moxifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-dependent QT prolongation, and moxifloxacin adds to this effect. The combination raises the risk of serious ventricular arrhythmia including torsades de pointes.
What this interaction means in plain words
Encorafenib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid concurrent use and select an antibiotic without QT effects. If it cannot be avoided, monitor ECG and electrolytes and consider reducing the encorafenib dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Moxifloxacin?
MediHelp rates the interaction as major. Encorafenib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib causes dose-dependent QT prolongation, and moxifloxacin adds to this effect. The combination raises the risk of serious ventricular arrhythmia including torsades de pointes.
How serious is the interaction between Encorafenib and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an antibiotic without QT effects. If it cannot be avoided, monitor ECG and electrolytes and consider reducing the encorafenib dose per labeling.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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