Drug interactions
Encorafenib + Nitrofurantoin
Severity: Minor
Encorafenib and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits BCRP in vitro, and nitrofurantoin is a BCRP substrate, so nitrofurantoin exposure might rise. The clinical significance is uncertain and probably small.
What this interaction means in plain words
Encorafenib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Encorafenib may inhibit BCRP-mediated efflux of nitrofurantoin.
What to do
No routine adjustment is needed; monitor for nitrofurantoin adverse effects such as gastrointestinal intolerance or neuropathy during extended use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Nitrofurantoin?
MediHelp rates the interaction as minor. Encorafenib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib inhibits BCRP in vitro, and nitrofurantoin is a BCRP substrate, so nitrofurantoin exposure might rise. The clinical significance is uncertain and probably small.
How serious is the interaction between Encorafenib and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for nitrofurantoin adverse effects such as gastrointestinal intolerance or neuropathy during extended use.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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