Drug interactions
Encorafenib + Norethisterone
Severity: Moderate
Encorafenib and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4, so norethisterone exposure may change unpredictably. Hormonal contraceptives may be less effective, and encorafenib labeling advises an alternative contraceptive method.
What this interaction means in plain words
Encorafenib and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Norethisterone belongs to Endocrine.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters norethisterone metabolism.
What to do
Advise an effective non-hormonal contraceptive method during encorafenib treatment and for a period after the last dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Norethisterone?
MediHelp rates the interaction as moderate. Encorafenib and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can both inhibit and induce CYP3A4, so norethisterone exposure may change unpredictably. Hormonal contraceptives may be less effective, and encorafenib labeling advises an alternative contraceptive method.
How serious is the interaction between Encorafenib and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective non-hormonal contraceptive method during encorafenib treatment and for a period after the last dose.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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