Drug interactions
Brigatinib + Norethisterone
Severity: Major
Brigatinib and Norethisterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4, which could lower norethisterone exposure and reduce contraceptive reliability. Breakthrough bleeding and unintended pregnancy are possible, which matters because brigatinib can harm the fetus.
What this interaction means in plain words
Brigatinib and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Norethisterone belongs to Endocrine.
Why it happens
Brigatinib induces CYP3A4 (shown in vitro), increasing the metabolism of norethisterone.
What to do
Use an effective nonhormonal contraceptive method during brigatinib treatment and for at least 4 months after the last dose. Do not rely on norethisterone alone for contraception.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Carbamazepine + Norethisterone Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Norethisterone?
MediHelp rates the interaction as major. Brigatinib and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may induce CYP3A4, which could lower norethisterone exposure and reduce contraceptive reliability. Breakthrough bleeding and unintended pregnancy are possible, which matters because brigatinib can harm the fetus.
How serious is the interaction between Brigatinib and Norethisterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective nonhormonal contraceptive method during brigatinib treatment and for at least 4 months after the last dose. Do not rely on norethisterone alone for contraception.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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