Drug interactions
Bosentan + Norethisterone
Severity: Major
Bosentan and Norethisterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower norethisterone exposure and reduce contraceptive reliability. Bosentan is also teratogenic, so contraceptive failure is a particular concern.
What this interaction means in plain words
Bosentan and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Norethisterone belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, increasing norethisterone clearance.
What to do
Do not rely on hormonal contraception alone, and use an additional or alternative non-hormonal method. Perform pregnancy testing as required by bosentan labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Brigatinib + Norethisterone Major
- Carbamazepine + Norethisterone Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bosentan with Norethisterone?
MediHelp rates the interaction as major. Bosentan and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may lower norethisterone exposure and reduce contraceptive reliability. Bosentan is also teratogenic, so contraceptive failure is a particular concern.
How serious is the interaction between Bosentan and Norethisterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on hormonal contraception alone, and use an additional or alternative non-hormonal method. Perform pregnancy testing as required by bosentan labeling.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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