Drug interactions
Encorafenib + Pravastatin
Severity: Moderate
Encorafenib and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may increase pravastatin exposure and raise the risk of statin-related muscle toxicity.
What this interaction means in plain words
Encorafenib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, reducing pravastatin uptake and efflux.
What to do
Monitor for muscle pain and weakness and consider reducing the pravastatin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Pravastatin?
MediHelp rates the interaction as moderate. Encorafenib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib may increase pravastatin exposure and raise the risk of statin-related muscle toxicity.
How serious is the interaction between Encorafenib and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and weakness and consider reducing the pravastatin dose if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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