Drug interactions
Apalutamide + Pravastatin
Severity: Moderate
Apalutamide and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may induce hepatic uptake transporters and lower pravastatin exposure. This could reduce the lipid-lowering effect.
What this interaction means in plain words
Apalutamide and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Pravastatin belongs to Cardiovascular.
Why it happens
Weak induction of OATP1B1 by apalutamide, reducing hepatic uptake and systemic exposure of pravastatin.
What to do
Monitor lipid response and increase the pravastatin dose if needed. Reassess lipids after starting or stopping apalutamide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Pravastatin?
MediHelp rates the interaction as moderate. Apalutamide and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may induce hepatic uptake transporters and lower pravastatin exposure. This could reduce the lipid-lowering effect.
How serious is the interaction between Apalutamide and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and increase the pravastatin dose if needed. Reassess lipids after starting or stopping apalutamide.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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