Drug interactions
Cyclosporin + Pravastatin
Severity: Major
Cyclosporin and Pravastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases pravastatin exposure several-fold, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Cyclosporin and Pravastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of pravastatin, increasing systemic concentrations.
What to do
Start pravastatin at 10 mg daily and do not exceed 20 mg daily. Counsel on muscle symptoms and check creatine kinase if they arise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pravastatin
Frequently asked questions
Can I take Cyclosporin with Pravastatin?
MediHelp rates the interaction as major. Cyclosporin and Pravastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine increases pravastatin exposure several-fold, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Cyclosporin and Pravastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pravastatin at 10 mg daily and do not exceed 20 mg daily. Counsel on muscle symptoms and check creatine kinase if they arise.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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