Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Pravastatin
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pravastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen increases pravastatin exposure, which raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pravastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Paritaprevir inhibits OATP1B1/1B3 and other transporters, reducing hepatic clearance of pravastatin.
What to do
Limit pravastatin to 40 mg daily during treatment and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pravastatin
- Cyclosporine + Pravastatin Major
- Cyclosporin + Pravastatin Major
- Gemfibrozil + Pravastatin Major
- Pravastatin + Red yeast rice Major
- Apalutamide + Pravastatin Moderate
- Bempedoic acid + Pravastatin Moderate
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Pravastatin?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pravastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This regimen increases pravastatin exposure, which raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pravastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit pravastatin to 40 mg daily during treatment and monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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