Drug interactions
Encorafenib + Rivaroxaban
Severity: Moderate
Encorafenib and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so its effect on rivaroxaban exposure is unpredictable and may lead to either bleeding or reduced anticoagulant efficacy.
What this interaction means in plain words
Encorafenib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Rivaroxaban belongs to Cardiovascular.
Why it happens
Mixed inhibition and induction of CYP3A4 (and possible transporter effects) alters rivaroxaban clearance.
What to do
Monitor for bleeding and for thromboembolic events, and consider an alternative anticoagulant if control is uncertain. Reassess when encorafenib is started, adjusted or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Rivaroxaban?
MediHelp rates the interaction as moderate. Encorafenib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so its effect on rivaroxaban exposure is unpredictable and may lead to either bleeding or reduced anticoagulant efficacy.
How serious is the interaction between Encorafenib and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and for thromboembolic events, and consider an alternative anticoagulant if control is uncertain. Reassess when encorafenib is started, adjusted or stopped.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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