Drug interactions
Encorafenib + Rosuvastatin
Severity: Moderate
Encorafenib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, which may increase rosuvastatin exposure. This raises the potential for statin-related muscle toxicity.
What this interaction means in plain words
Encorafenib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3 and BCRP transporters reduces rosuvastatin uptake and efflux.
What to do
Monitor for muscle pain, weakness or CK elevation and consider lowering the rosuvastatin dose if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Rosuvastatin?
MediHelp rates the interaction as moderate. Encorafenib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits OATP1B1, OATP1B3 and BCRP, which may increase rosuvastatin exposure. This raises the potential for statin-related muscle toxicity.
How serious is the interaction between Encorafenib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or CK elevation and consider lowering the rosuvastatin dose if they develop.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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