Drug interactions
Encorafenib + Sirolimus
Severity: Moderate
Encorafenib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so sirolimus exposure may rise or fall unpredictably. Subtherapeutic levels risk rejection, while high levels increase toxicity.
What this interaction means in plain words
Encorafenib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib alters sirolimus metabolism.
What to do
Monitor sirolimus trough concentrations frequently after starting, changing or stopping encorafenib, and adjust the sirolimus dose to the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Sirolimus?
MediHelp rates the interaction as moderate. Encorafenib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so sirolimus exposure may rise or fall unpredictably. Subtherapeutic levels risk rejection, while high levels increase toxicity.
How serious is the interaction between Encorafenib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations frequently after starting, changing or stopping encorafenib, and adjust the sirolimus dose to the target range.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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