Drug interactions
Encorafenib + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Encorafenib and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib inhibits BCRP and has mixed inhibiting and inducing effects on CYP3A4. Velpatasvir exposure may increase through BCRP inhibition, or decrease through induction, so effects are unpredictable.
What this interaction means in plain words
Encorafenib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Encorafenib inhibits BCRP and both inhibits and induces CYP3A4, altering velpatasvir and voxilaprevir disposition.
What to do
Monitor for adverse effects of the antiviral regimen and confirm sustained virologic response. Consider an alternative if efficacy appears compromised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Encorafenib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib inhibits BCRP and has mixed inhibiting and inducing effects on CYP3A4. Velpatasvir exposure may increase through BCRP inhibition, or decrease through induction, so effects are unpredictable.
How serious is the interaction between Encorafenib and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the antiviral regimen and confirm sustained virologic response. Consider an alternative if efficacy appears compromised.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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