Drug interactions
Enoxaparin + Etodolac
Severity: Major
Enoxaparin and Etodolac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac impairs platelet function and can cause gastrointestinal ulceration, so combined with enoxaparin it increases the risk of bleeding, including spinal or epidural hematoma around neuraxial procedures.
What this interaction means in plain words
Enoxaparin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enoxaparin belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: NSAID platelet inhibition and mucosal injury plus enoxaparin anti-Xa and anti-IIa activity.
What to do
Avoid NSAIDs where possible and use paracetamol. If combined, monitor hemoglobin and for bleeding and follow neuraxial anesthesia timing precautions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Etodolac?
MediHelp rates the interaction as major. Enoxaparin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac impairs platelet function and can cause gastrointestinal ulceration, so combined with enoxaparin it increases the risk of bleeding, including spinal or epidural hematoma around neuraxial procedures.
How serious is the interaction between Enoxaparin and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol. If combined, monitor hemoglobin and for bleeding and follow neuraxial anesthesia timing precautions.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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