Drug interactions
Enoxaparin + Fosinopril-hydrochlorothiazide
Severity: Moderate
Enoxaparin and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins suppress aldosterone synthesis, and with ACE inhibitors this can lead to hyperkalemia, particularly with renal impairment, diabetes or prolonged use. The thiazide component partly counteracts this.
What this interaction means in plain words
Enoxaparin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of adrenal aldosterone secretion adds to ACE inhibitor-mediated reduction in potassium excretion.
What to do
Monitor serum potassium in patients on prolonged enoxaparin or with renal impairment or diabetes. Treat hyperkalemia if it develops and reassess the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Enoxaparin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins suppress aldosterone synthesis, and with ACE inhibitors this can lead to hyperkalemia, particularly with renal impairment, diabetes or prolonged use. The thiazide component partly counteracts this.
How serious is the interaction between Enoxaparin and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on prolonged enoxaparin or with renal impairment or diabetes. Treat hyperkalemia if it develops and reassess the combination.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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