Drug interactions
Enoxaparin + Imatinib
Severity: Moderate
Enoxaparin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and other cytopenias, which raises the bleeding risk of enoxaparin. Low molecular weight heparin is often preferred over warfarin in patients on imatinib because warfarin has more interaction mechanisms.
What this interaction means in plain words
Enoxaparin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Additive bleeding risk through imatinib-related thrombocytopenia combined with enoxaparin anticoagulation.
What to do
Check the platelet count at baseline and regularly during combined therapy, and reduce or hold enoxaparin if platelets fall significantly. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Enoxaparin with Imatinib?
MediHelp rates the interaction as moderate. Enoxaparin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and other cytopenias, which raises the bleeding risk of enoxaparin. Low molecular weight heparin is often preferred over warfarin in patients on imatinib because warfarin has more interaction mechanisms.
How serious is the interaction between Enoxaparin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the platelet count at baseline and regularly during combined therapy, and reduce or hold enoxaparin if platelets fall significantly. Monitor for bleeding.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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