Drug interactions
Enoxaparin + Ketoprofen
Severity: Major
Enoxaparin and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant use increases the risk of bleeding, notably gastrointestinal, and spinal or epidural hematoma in neuraxial settings. The risk is higher in older or renally impaired patients.
What this interaction means in plain words
Enoxaparin and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enoxaparin belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic effects of antithrombin-mediated anticoagulation, NSAID platelet inhibition and mucosal injury.
What to do
Discontinue the NSAID if possible, or monitor closely for bleeding and hemoglobin; use paracetamol as an alternative analgesic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Ketoprofen?
MediHelp rates the interaction as major. Enoxaparin and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concomitant use increases the risk of bleeding, notably gastrointestinal, and spinal or epidural hematoma in neuraxial settings. The risk is higher in older or renally impaired patients.
How serious is the interaction between Enoxaparin and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue the NSAID if possible, or monitor closely for bleeding and hemoglobin; use paracetamol as an alternative analgesic.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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