Drug interactions
Enoxaparin + Oxaprozin
Severity: Major
Enoxaparin and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin anticoagulation combined with NSAID platelet inhibition and gastric irritation increases bleeding risk, including gastrointestinal and spinal or epidural hematoma in susceptible settings.
What this interaction means in plain words
Enoxaparin and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enoxaparin belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: enoxaparin enhances antithrombin-mediated factor Xa inhibition while the NSAID impairs platelet function and damages mucosa.
What to do
Avoid concurrent NSAID use where possible and use acetaminophen instead. If co-administered, monitor for bleeding and hemoglobin, and stop the NSAID if bleeding occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Oxaprozin?
MediHelp rates the interaction as major. Enoxaparin and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enoxaparin anticoagulation combined with NSAID platelet inhibition and gastric irritation increases bleeding risk, including gastrointestinal and spinal or epidural hematoma in susceptible settings.
How serious is the interaction between Enoxaparin and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use where possible and use acetaminophen instead. If co-administered, monitor for bleeding and hemoglobin, and stop the NSAID if bleeding occurs.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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