Drug interactions
Enoxaparin + Roxithromycin
Severity: Minor
Enoxaparin and Roxithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin is cleared mainly renally and is not metabolized by CYP3A4, so inhibition by roxithromycin should not change its exposure. No clinically meaningful interaction is established.
What this interaction means in plain words
Enoxaparin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enoxaparin belongs to Cardiovascular; Roxithromycin belongs to Anti Bacterial.
Why it happens
No established mechanism; enoxaparin is not a CYP substrate.
What to do
No adjustment is needed; use usual monitoring for enoxaparin, including renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Roxithromycin
- Digoxin + Roxithromycin Major
- Argatroban + Roxithromycin Moderate
- Cyclosporin + Roxithromycin Moderate
- Roxithromycin + Tacrolimus Moderate
- Ampicillin-sulbactam + Roxithromycin Minor
- Ampicillin + Roxithromycin Minor
Frequently asked questions
Can I take Enoxaparin with Roxithromycin?
MediHelp rates the interaction as minor. Enoxaparin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enoxaparin is cleared mainly renally and is not metabolized by CYP3A4, so inhibition by roxithromycin should not change its exposure. No clinically meaningful interaction is established.
How serious is the interaction between Enoxaparin and Roxithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; use usual monitoring for enoxaparin, including renal function.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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