Drug interactions
Enoxaparin + Sulindac
Severity: Major
Enoxaparin and Sulindac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac impairs platelet function and can injure the gastrointestinal mucosa, while enoxaparin provides anticoagulation. The combination increases the risk of bleeding, including spinal or epidural hematoma in neuraxial settings.
What this interaction means in plain words
Enoxaparin and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enoxaparin belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: NSAID antiplatelet action and mucosal injury plus low molecular weight heparin anticoagulation.
What to do
Avoid concurrent use where possible and use paracetamol for pain. If both are needed, monitor closely for bleeding and check hemoglobin and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Sulindac?
MediHelp rates the interaction as major. Enoxaparin and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulindac impairs platelet function and can injure the gastrointestinal mucosa, while enoxaparin provides anticoagulation. The combination increases the risk of bleeding, including spinal or epidural hematoma in neuraxial settings.
How serious is the interaction between Enoxaparin and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and use paracetamol for pain. If both are needed, monitor closely for bleeding and check hemoglobin and renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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