Drug interactions
Enoxaparin + Ticagrelor
Severity: Moderate
Enoxaparin and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a P2Y12 antagonist with a low molecular weight heparin increases the risk of bleeding. This pairing is frequently used deliberately in acute coronary syndromes, so the added risk is accepted but must be managed.
What this interaction means in plain words
Enoxaparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive haemostatic impairment from platelet P2Y12 receptor blockade by ticagrelor and inhibition of coagulation factors Xa and IIa by enoxaparin.
What to do
Use only when there is a clear indication and monitor for bleeding, haemoglobin and platelet count. Limit the duration of parenteral anticoagulation to what is needed and adjust enoxaparin for renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Enoxaparin with Ticagrelor?
MediHelp rates the interaction as moderate. Enoxaparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a P2Y12 antagonist with a low molecular weight heparin increases the risk of bleeding. This pairing is frequently used deliberately in acute coronary syndromes, so the added risk is accepted but must be managed.
How serious is the interaction between Enoxaparin and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when there is a clear indication and monitor for bleeding, haemoglobin and platelet count. Limit the duration of parenteral anticoagulation to what is needed and adjust enoxaparin for renal impairment.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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