Drug interactions
Entacapone + Epinephrine
Severity: Moderate
Entacapone and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone inhibits COMT, one of the enzymes that breaks down epinephrine. This may prolong and amplify the cardiovascular effects of epinephrine, such as tachycardia, arrhythmia and hypertension.
What this interaction means in plain words
Entacapone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entacapone belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
COMT inhibition by entacapone reduces the metabolic inactivation of epinephrine.
What to do
Monitor heart rate, rhythm and blood pressure when epinephrine is given. Use the lowest effective epinephrine dose and be prepared to reduce it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Entacapone with Epinephrine?
MediHelp rates the interaction as moderate. Entacapone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entacapone inhibits COMT, one of the enzymes that breaks down epinephrine. This may prolong and amplify the cardiovascular effects of epinephrine, such as tachycardia, arrhythmia and hypertension.
How serious is the interaction between Entacapone and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure when epinephrine is given. Use the lowest effective epinephrine dose and be prepared to reduce it.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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