Drug interactions
Entacapone + Fentanyl
Severity: Minor
Entacapone and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone may cause somnolence and dizziness, which can add to the CNS depression produced by fentanyl. The combination may increase drowsiness and impair psychomotor function.
What this interaction means in plain words
Entacapone and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; no pharmacokinetic mechanism is established.
What to do
Start fentanyl at the lowest effective dose and monitor for excessive sedation. Advise patients to avoid driving or operating machinery until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Entacapone with Fentanyl?
MediHelp rates the interaction as minor. Entacapone and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entacapone may cause somnolence and dizziness, which can add to the CNS depression produced by fentanyl. The combination may increase drowsiness and impair psychomotor function.
How serious is the interaction between Entacapone and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start fentanyl at the lowest effective dose and monitor for excessive sedation. Advise patients to avoid driving or operating machinery until the response is known.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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