Drug interactions
Entacapone + Infigratinib
Severity: Minor
Entacapone and Infigratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized by CYP3A4, and inhibitors of this enzyme can increase its exposure. Entacapone is not an established CYP3A4 inhibitor, so any effect is theoretical.
What this interaction means in plain words
Entacapone and Infigratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical CYP3A4 inhibition by entacapone; not established clinically.
What to do
No empirical dose adjustment is needed; monitor for infigratinib toxicity such as hyperphosphatemia and ocular effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Entacapone with Infigratinib?
MediHelp rates the interaction as minor. Entacapone and Infigratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infigratinib is metabolized by CYP3A4, and inhibitors of this enzyme can increase its exposure. Entacapone is not an established CYP3A4 inhibitor, so any effect is theoretical.
How serious is the interaction between Entacapone and Infigratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for infigratinib toxicity such as hyperphosphatemia and ocular effects.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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