Drug interactions
Entrectinib + Fluoxetine
Severity: Major
Entrectinib and Fluoxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QTc interval, and fluoxetine can add to this effect. Together they raise the risk of torsades de pointes. Fluoxetine's moderate CYP3A4 inhibition may also raise entrectinib exposure.
What this interaction means in plain words
Entrectinib and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising entrectinib levels.
What to do
Avoid if possible, or monitor ECG and electrolytes at baseline and periodically. Reduce or interrupt entrectinib if significant QT prolongation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Fluoxetine?
MediHelp rates the interaction as major. Entrectinib and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QTc interval, and fluoxetine can add to this effect. Together they raise the risk of torsades de pointes. Fluoxetine's moderate CYP3A4 inhibition may also raise entrectinib exposure.
How serious is the interaction between Entrectinib and Fluoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or monitor ECG and electrolytes at baseline and periodically. Reduce or interrupt entrectinib if significant QT prolongation occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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