Drug interactions
Entrectinib + Formoterol-mometasone
Severity: Moderate
Entrectinib and Formoterol-mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval. Formoterol may add to this effect and lower serum potassium, which could raise the risk of serious arrhythmia.
What this interaction means in plain words
Entrectinib and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Formoterol-mometasone belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia as a contributor.
What to do
Monitor ECG and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Formoterol-mometasone?
MediHelp rates the interaction as moderate. Entrectinib and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval. Formoterol may add to this effect and lower serum potassium, which could raise the risk of serious arrhythmia.
How serious is the interaction between Entrectinib and Formoterol-mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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