Drug interactions
Entrectinib + Imatinib
Severity: Major
Entrectinib and Imatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib, a moderate CYP3A4 inhibitor, can increase entrectinib exposure. This raises the risk of QT prolongation, heart failure, cognitive effects and other dose-related toxicity.
What this interaction means in plain words
Entrectinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of entrectinib.
What to do
Avoid if possible. If it is required, reduce the entrectinib dose per labeling, monitor ECG and for neurologic and cardiac toxicity, and restore the dose 3-5 half-lives after imatinib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entrectinib and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Imatinib?
MediHelp rates the interaction as major. Entrectinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib, a moderate CYP3A4 inhibitor, can increase entrectinib exposure. This raises the risk of QT prolongation, heart failure, cognitive effects and other dose-related toxicity.
How serious is the interaction between Entrectinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If it is required, reduce the entrectinib dose per labeling, monitor ECG and for neurologic and cardiac toxicity, and restore the dose 3-5 half-lives after imatinib is stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
