Drug interactions
Entrectinib + Ipratropium-salbutamol
Severity: Moderate
Entrectinib and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and salbutamol may add to this effect, particularly with hypokalemia or high-dose use. The risk is greatest in patients with other proarrhythmic factors.
What this interaction means in plain words
Entrectinib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Monitor ECG and serum electrolytes, and correct potassium and magnesium abnormalities. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Entrectinib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and salbutamol may add to this effect, particularly with hypokalemia or high-dose use. The risk is greatest in patients with other proarrhythmic factors.
How serious is the interaction between Entrectinib and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum electrolytes, and correct potassium and magnesium abnormalities. Use the lowest effective salbutamol dose.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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