Drug interactions
Entrectinib + Levofloxacin
Severity: Major
Entrectinib and Levofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is associated with QT prolongation, and levofloxacin adds to this effect. The combination raises the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Entrectinib and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation through effects on cardiac repolarization.
What to do
Avoid if an alternative antibiotic is available. If used together, obtain a baseline and follow-up ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Levofloxacin?
MediHelp rates the interaction as major. Entrectinib and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib is associated with QT prolongation, and levofloxacin adds to this effect. The combination raises the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Entrectinib and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic is available. If used together, obtain a baseline and follow-up ECG and keep potassium and magnesium normal.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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