Drug interactions
Entrectinib + Memantine-donepezil
Severity: Moderate
Entrectinib and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and donepezil adds a similar effect. The combination may raise the risk of ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes before and during therapy. Withhold or reduce entrectinib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Memantine-donepezil?
MediHelp rates the interaction as moderate. Entrectinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and donepezil adds a similar effect. The combination may raise the risk of ventricular arrhythmias.
How serious is the interaction between Entrectinib and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during therapy. Withhold or reduce entrectinib if QTc becomes significantly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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