Drug interactions
Entrectinib + Quetiapine
Severity: Major
Entrectinib and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib and quetiapine each have the potential to lengthen the QTc interval. Together they increase the likelihood of clinically significant QT prolongation and torsades de pointes.
What this interaction means in plain words
Entrectinib and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination if an alternative antipsychotic is possible. Otherwise obtain a baseline ECG, monitor QTc and electrolytes, and stop or reduce a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Quetiapine?
MediHelp rates the interaction as major. Entrectinib and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib and quetiapine each have the potential to lengthen the QTc interval. Together they increase the likelihood of clinically significant QT prolongation and torsades de pointes.
How serious is the interaction between Entrectinib and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antipsychotic is possible. Otherwise obtain a baseline ECG, monitor QTc and electrolytes, and stop or reduce a drug if QTc becomes markedly prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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