Drug interactions
Entrectinib + Sertraline
Severity: Moderate
Entrectinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is a CYP3A4 substrate that can prolong the QT interval. Sertraline is a weak CYP3A4 inhibitor, so the kinetic effect is probably minor, but its small QT effect may add to that of entrectinib.
What this interaction means in plain words
Entrectinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus possible minor CYP3A4 inhibition by sertraline raising entrectinib exposure.
What to do
Check a baseline ECG and electrolytes, then monitor the ECG during co-therapy. Reduce or interrupt entrectinib if the QTc becomes markedly prolonged, and consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Sertraline?
MediHelp rates the interaction as moderate. Entrectinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib is a CYP3A4 substrate that can prolong the QT interval. Sertraline is a weak CYP3A4 inhibitor, so the kinetic effect is probably minor, but its small QT effect may add to that of entrectinib.
How serious is the interaction between Entrectinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, then monitor the ECG during co-therapy. Reduce or interrupt entrectinib if the QTc becomes markedly prolonged, and consider an alternative antidepressant.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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